Antibody Cloning
We generate antibody clones from phage display clones (single chain variable fragment scFv format), cDNA or protein sequence data or hybridoma cells.
We perform the sequence analysis, oligo design, expression cassette cloning and optimisation followed by DNA production of the antibody expression clones. You can receive a simple report of the sequence analysis.
We can also produce the antibody protein product via transient transfection, and we’ll ship the protein product and a report regarding the sequence, purity and concentration. Alternatively, we can generate a stable cell line and deliver the antibody-producing cells and/or a supply of purified antibody product to you.
Antibody Sequence Optimization
We also provide antibody sequence optimization to improve antibody production rates of mammalian expression systems, including sequence modifications to stabilize the RNA and optimize codon usage.
Our antibody modification services include re-cloning in different formats and isoforms, chimerization, humanization, and affinity maturation; various methods applying mutagenesis, phage display and clonal selection to achieve the highest affinity antibody cell clones.
For further information on our antibody cloning, sequence optimization or modification services, please contact us.
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