Modiquest Research offers contract research on the generation of animal and human recombinant monoclonal antibodies

ModiQuest Research (CRO) focus is on generation of recombinant monoclonal antibodies (animal, human). We use antigen specific B-cell selection combined with efficient hybridoma generation or direct antibody cDNA cloning from selected B-cells. MQR offers custom phage display services. contract research, technology patents, licenses, recombinant antibody services, phage display services, antibody based activity assay for peptidyl arginin deiminases (ABAP), collagen antibody induced arthritis animal model (CAIA), generation of stable recombinant antibody producing cell lines, mouse and human peptidyl arginin deiminase enzymes, proprietary human and mouse antibodies for proteomics and diagnostics, human autoantigens, apoptotic cleavage product, protein, hU1-70K, hU1-C, hJo-1, hRpp20, hRrp4, sdab, scfv, fab, pad, cancer, multiple sclerosis, rheumatoid arthritis, Animal model, Anti Citrulline Peptide Antibodies, Antibodies, Antibody, Antibody expression, anti-CCP, Antigen Specific B-cell Selection, arthritis, B-cell, B-cell culture, B-cell selection, Biotechnology, CAIA, CCP, CCP Antibodies, chicken, Collagen Antibody Induced Arthritis Animal Model, Contract Research, CRO, gene synthesis, Generation of Stable Recombinant Antibody Producing Cell Line, llama, mouse, neo epitope, Phage Display, Post translational Protein Modification, Proprietary Antibodies, Rabbit, Rare Antibody Specificities, ecombinant (Human) Auto-Antibodies, recombinant antibodies, recombinant antibody, Recombinant antibody cloning, Recombinant Antibody Cloning and Expression, Recombinant antibody expression,Recombinant Chimeric Antibodies, Recombinant Human Antibodies, Recombinant Mouse antibodies. stable cell line <table cellspacing="0" cellpadding="0" border="0" align="center" width="100%"> <tbody> <tr> <td align="center" colspan="3"><strong><font size="3">Modiquest Research; high quality products and contract research in antibody discovery, development and  production.</font></strong> </td> </tr> <tr> <td colspan="2"> </td> <td valign="middle" align="center"> <img width="580" src="downloads/Image/Technology platform MQR-c-web.jpg" alt=""/></td> </tr> <tr> <td colspan="3">ModiQuest Research focuses on feasibility, early development, and pilot scale research projects in the (recombinant) antibody field. More in particular, ModiQuest Research is specialized in the generation of human antibodies against difficult targets, such as antibodies specific for post-translationally modified (neo) epitopes.</td> </tr> <tr> <td colspan="2"> </td> <td> <p align="right"> <a align="center" type="Video" target="_blank" href="http://www.modiquestresearch.com/video/" title="Click here for Company Video Introduction" id="Company Video Introduction"><u><font color="#0000ff">Company Video Introduction</font></u></a></p> </td> </tr> </tbody> </table> <div> </div> <div> </div> <div> </div> <div> </div> <div> </div> <div><map name="MQRwebsitemap"><br/> <area shape="RECT" coords="6,4,505,354" map="" href="http://www.modiquestresearch.com/video/" target="_blank" title="Click here for Company Video Introduction"/></map></div><em><font size="2"><span style="FONT-FAMILY: Arial; FONT-SIZE: 10pt" lang="EN-GB"></span></font></em> <div> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"> <p><font face="Arial"><strong>Modiquest Research B.V.</strong></font></p> <p><font face="Arial">Mobile  +31 (0)6-24983974<br/> Phone  +31 (0)24-3614253 <br/> Fax      +31 (0)24-3613658</font></p> <p><a href="mailto:info@modiquestresearch.com?subject=Web%20inquiry"><font face="Arial">info@modiquestresearch.com</font></a><br/> <a href="http://www.modiquestresearch.com/"><font face="Arial">www.modiquestresearch.com</font></a></p> <p> </p> </td> <td valign="top" colspan="2" align="left"> <p align="right"> </p> </td> <td> <p align="left"><img alt="" align="top" src="http://www.modiquestresearch.com/website/downloads/Image/huygens%20gebouw.jpg" width="225" height="145"/></p> </td> </tr> <tr> <td valign="top" align="left"> <p><font face="Arial"></font></p> <font face="Arial"><em> <p><font face="Arial"><em>Postal address & </em></font>Visiting address:</p> </em></font> <p><font face="Arial">Innovation lab <br/> Heyendaalseweg 135<br/> 6525 AJ Nijmegen<br/> The Netherlands</font> </p> </td> <td valign="top" colspan="2" align="left"> <p><font face="Arial"></font></p> <p><font face="Arial"></font></p> </td> <td valign="top" align="left"> <p><font face="Arial"></font></p> <p><font face="Arial"><em>Delivery address:</em></font></p> <p><font face="Arial">ModiQuest Research <br/> Logistiek Centrum FNWI <br/> Toernooiveld 8 <br/> 6525 ED Nijmegen <br/> The Netherlands</font></p> </td> </tr> <tr> <td valign="top" align="left"> </td> <td valign="top" colspan="2" align="left"> </td> <td valign="top" align="left"> <p align="left"> </p> <p align="left"><a id="Company Video Introduction" title="Click here for Company Video Introduction" href="http://www.modiquestresearch.com/video/" type="Video" target="_blank" align="center"><u><font color="#0000ff">Company Video Introduction</font></u></a></p> </td> </tr> </tbody> </table> </div> <div> </div><p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><strong></strong></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4"></font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4"></font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4"></font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4"></font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font color="#ff0000" size="4"></font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">ModiQuest Research: high quality products and contract research in </font></strong></font></font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">antibody discovery, development, and production.</font> </strong> <p align="justify"><font size="3">ModiQuest Research is a biotechnology company specialized in the generation of human and animal antibodies. ModiQuest Research provides state of the art antibody generation and optimisation. Our services encompass feasibility analyses, antibody discovery, selection, optimization, and pilot scale production.</font> </p> <p align="justify"><font size="3">ModiQuest Research works for large and small leading pharmaceutical and diagnostic companies. In addition ModiQuest Research supports academic research programs.</font> </p> </font></font></span></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p align="center"> </p><p dir="ltr" style="MARGIN-RIGHT: 0px" align="left"><font face="Verdana">ModiQuest Research offers </font></p> <p><strong><font face="Verdana">Contract Research for Technology Development in the Recombinant Antibody Field:</font></strong></p> <p><font face="Verdana"> <table cellspacing="1" cellpadding="0" width="100%" border="0"> <tbody> <tr> <td valign="middle" align="left" colspan="2"> <p><font face="Verdana"></font></p> <div> <li><font face="Verdana"><strong>Protein expression and purification </strong></font></li> <li><font face="Verdana"><strong>(Re)cloning of antibody domains </strong></font></li> <li><font face="Verdana"><strong>Tissue culture  </strong> <li><font face="Verdana"><strong>Bacterial cloning </strong></font></li> <li><strong><font face="Verdana">Library construction </font> </strong><font face="Verdana"><strong><br/> </strong></font></li> </font></li> </div> </td> <td valign="middle" align="center" rowspan="2"> <div><strong> <img height="219" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/tissue2.jpg" width="186"/> </strong></div> </td> </tr> <tr> <td valign="top"> <div><strong> </strong></div> </td> <td valign="top"> <div><i></i></div> </td> </tr> </tbody> </table> </font></p><span id="_ctl2_CompanyPreviewCtrl_CompanyDescription" class="BodyText"> <table border="0" cellspacing="2" cellpadding="2" width="100%"> <tbody> <tr> <td valign="middle" align="left"><span class="BodyText"><span class="BodyText"><span id="_ctl2_CompanyPreviewCtrl_DetailCompanyDescriptionSpan"><span id="_ctl2_CompanyPreviewCtrl_DetailCompanyDescription" class="BodyText"> <div align="justify"><span style="LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri" lang="EN-GB">ModiQuest Research, </span><span style="LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: Calibri" lang="EN-GB"><span class="bodytext"><span style="mso-ansi-language: EN-GB" lang="EN-GB">founded early 2005 as a private company, is a contract research provider focused on the generation of (recombinant) monoclonal antibodies from various species.</span></span></span></div> </span></span></span></span></td> <td valign="top" align="center"> <p><strong><span style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 12pt; mso-ansi-language: NL; mso-fareast-language: NL; mso-bidi-language: AR-SA"><shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"></shapetype><font size="2" face="Verdana"> </font><a id="Click here for Company Video Introduction" title="Click here for Company Video Introduction" href="http://www.modiquestresearch.com/video/" type="Click here for Company Video Introduction" target="_blank"><font size="2" face="Verdana"><img alt="" align="absBottom" src="http://www.modiquestresearch.com/website/downloads/Image/360web.jpg"/></font></a></span></strong><font face="Verdana"> <br/> <span style="FONT-FAMILY: calibri; COLOR: black; FONT-SIZE: 12pt; mso-ansi-language: NL; mso-fareast-language: NL; mso-bidi-language: AR-SA"></span><span style="FONT-FAMILY: Calibri; COLOR: black; FONT-SIZE: 12pt; mso-ansi-language: NL; mso-fareast-language: NL; mso-bidi-language: AR-SA"><shapetype coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"></shapetype></span></font><a title="please click for video introduction" href="http://www.modiquestresearch.com/video/" target="_blank"><font face="Verdana">Jos Raats Ph.D. CEO</font></a><font face="calibri"> </font></p> </td> </tr> </tbody> </table> <span class="BodyText"><span id=""><span id="" class="BodyText"> <table border="0" cellspacing="2" cellpadding="2" width="100%"> <tbody> <tr> <td> <p align="justify"><font face="Calibri"><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">ModiQuest Research is a young and dynamic biotech company specialized in high throughput  genera</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold" lang="EN-GB">ti</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">on of human and animal (recombinant) an</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold" lang="EN-GB">ti</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">bodies, especially for application in the fields of autoimmune diseases, infec</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold" lang="EN-GB">ti</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">ous diseases, and cancer. Antibodies are generated using a large panel of state-of-the art technologies and can be used for diagnos</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold" lang="EN-GB">ti</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">c and therapeu</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold" lang="EN-GB">ti</span><span style="FONT-FAMILY: Calibri; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA; mso-bidi-font-family: Calibri-Bold; mso-bidi-font-weight: bold" lang="EN-GB">c purposes.</span></font></p> </td> </tr> </tbody> </table> <table border="0" cellspacing="2" cellpadding="2" width="100%"> <tbody> <tr> <td> <p align="justify"><font face="calibri"><span style="FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-font-family: Calibri" lang="EN-GB">To provide its high quality services, ModiQuest Research uses ultra modern facilities with state-of-the-art equipment, has a staff of highly skilled and experienced employees, and holds licenses for various antibody technologies. </span></font></p> <p align="right"><font face="calibri"><span style="FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-font-family: Calibri" lang="EN-GB"><a id="Company Video Introduction" title="Click here for Company Video Introduction" href="http://www.modiquestresearch.com/video/" type="Video" target="_blank" align="center"><u><font color="#0000ff">Company Video Introduction</font></u></a></span></font></p> </td> </tr> </tbody> </table> </span></span></span> <p><font face="Verdana">  <p align="right"> </p> </font></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p><font face="Verdana"> </font></p> </span><span lang="EN-US" style="FONT-SIZE: 11pt; FONT-FAMILY: `Times New Roman`; mso-ansi-language: EN-US; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><span lang="EN-US" style="COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-US"><span lang="EN-US" style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-US"> <p align="justify"><span lang="EN-US" style="FONT-SIZE: 11pt; FONT-FAMILY: `Times New Roman`; mso-ansi-language: EN-US; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><span><font face="Arial"><span class="BodyText" id="_ctl2_CompanyPreviewCtrl_CompanyDescription"><font size="3"><span class="BodyText" id="_ctl3_CompanyDescription"><font size="2"><strong>ModiQuest Research</strong> is a contract research organisation focused on generation of recombinant monoclonal antibodies from various species (animal, human). ModiQuest Research uses state of the art technologies like antigen specific B-cell selection, combined with efficient hybridoma generation, or direct antibody cDNA cloning from selected B-cells. ModiQuest Research also offers custom phage display services.</font></span> </font></span></font></span></span></p> <p align="justify"><span lang="EN-US" style="FONT-SIZE: 11pt; FONT-FAMILY: `Times New Roman`; mso-ansi-language: EN-US; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><span><font face="Arial"><span class="BodyText"><font size="2"><span lang="EN-US" style="FONT-SIZE: 11pt; FONT-FAMILY: `Times New Roman`; mso-ansi-language: EN-US; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><em><font size="1">Contract research is performed in close collaboartion with </font></em><a href="http://www.modiquest.com/" target="_blank"><font color="#810081" size="1"><em><u>Modiquest B.V.</u></em></font></a></span><font size="3"> </font> <p align="justify"><u><font color="#810081"></font></u></p> <p align="justify"> </p> <p><br/> </p> </font></span></font></span></span></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> </span></span></span><div><strong></strong></div> <br/> <div><strong>ModiQuest Research</strong> focuses on feasibility, early development and pilot scale research projects related to recombinant antibodies. We specialize in the generation of antibodies against difficult targets such as antibodies specific for post-translationally modified (neo) epitopes. </div> <p><font face="Verdana"><strong>ModiQuest Research</strong> offers state of the art technology in:</font></p> <p> <table cellspacing="1" cellpadding="0" width="100%" border="0"> <tbody> <tr> <td valign="top" colspan="2"> <p><font face="Verdana"><strong>> High throughput hybridoma generation</strong></font></p> </td> <td valign="middle" align="center" rowspan="4"> <div align="right"> <img style="WIDTH: 150px; HEIGHT: 100px" height="123" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/tissue3.jpg" width="174"/></div> </td> </tr> <tr> <td valign="top"> <div>     </div> </td> <td> <div><i>Antigen specific B-cell selection and culture </i><i><br/> </i><i>Antibody cloning from antigen specific B-cells</i><i><br/> </i><i>Antibody sequencing and cloning from hybridomas</i></div> </td> </tr> <tr> <td valign="top" colspan="2"> <div>     </div> </td> </tr> <tr> <td valign="top" colspan="2"> <div><strong>> Phage display library construction and screening</strong></div> </td> </tr> <tr> <td valign="top" colspan="2"> <div>     </div> </td> <td valign="top"> <div align="right"> </div> </td> </tr> <tr> <td valign="top" colspan="2"> <div><strong>> High throughput stable (antibody producing) cell line generation</strong></div> </td> <td valign="middle" align="center" rowspan="7"> <div align="right"><img style="WIDTH: 148px; HEIGHT: 92px" height="130" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/labfoto025small.jpg" width="233"/> </div> </td> </tr> <tr> <td valign="top"> <div>      </div> </td> <td> <div><em>MQR-vectors available for expressing recombinant (chimeric) human, mouse and chicken antibodies </em></div> </td> </tr> <tr> <td valign="top"> <div> </div> </td> <td> <div>     </div> </td> </tr> <tr> <td valign="top" colspan="2"> <div><strong>> Animal Models for Rheumatoid Arthritis</strong>  <a href="http://www.modiquestresearch.com/website/show.php?id=8&menuid=20">>> learn more >></a></div> </td> </tr> <tr> <td valign="top" colspan="2"> <div>     </div> </td> </tr> <tr> <td valign="top" colspan="2"> <div><strong>> Proprietary Enzyme Acitvity Assays</strong>  <a href="http://www.modiquestresearch.com/website/show.php?id=11&menuid=25">>> learn more >></a></div> </td> </tr> </tbody> </table> </p> <p><font face="Verdana"></font></p> <p><font face="Verdana"></font></p> <br/> <br/> <p><font face="Verdana">To download our technology brochures, please </font><a href="http://www.modiquestresearch.com/website/show.php?id=30"><font face="Verdana">click here</font></a><font face="Verdana">.</font></p><br/> <div>ModiQuest Research offers</div> <p><font face="Verdana"><strong>Proprietary Antigen Specific B-cell selection</strong></font></p> <ul> <li><font face="Verdana">for highly efficient </font><a href="http://www.modiquestresearch.com/website/show.php?id=23&menuid=29"><font face="Verdana">hybridoma generation</font></a><font face="Verdana"> </font></li> <li><font face="Verdana">for direct antibody cDNA cloning from antigen specific B-cells </font></li> </ul> <p align="justify"> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"> <p align="justify"><font face="Verdana">Antigen specific B-cell selection offers a fast and efficient opportunity to generate recombinant monoclonal antibodies from various species such as mouse, human, llama, chicken, rabbit etc</font></p> <p align="justify"><font face="Verdana">Difficult and rare antibody specificities can be generated using B-cell panning technology.</font></p> </td> <td> <p><font face="Verdana"> <img style="WIDTH: 78px; HEIGHT: 102px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Muisrechtop.jpg" width="149" height="200"/></font></p> </td> </tr> <tr> <td valign="top" align="left"><font face="Verdana">ModiQuest Research focuses on the generation of monoclonal antibodies specific for post-translationally modified (neo) epitopes. For more information please </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=39" target="_blank"><font face="Verdana">click here</font></a><font face="Verdana"> (PDF 2Mb).</font></td> <td valign="top" align="left"> <p align="justify"><font face="Verdana"> </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=39"><font face="Verdana"><img style="WIDTH: 77px; HEIGHT: 108px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Recombinant%20Antibody%20brochure.jpg" width="158" height="182"/></font></a></p> </td> </tr> </tbody> </table> </p> <p align="justify"><font face="Verdana"> </font></p> <p align="justify"><font face="Verdana"> </font></p><p align="justify"> </p> <p align="justify"> <table cellspacing="2" cellpadding="2" width="100%" border="0"> <tbody> <tr> <td valign="top" align="left"> <p><strong>ModiQuest Research</strong> has developed an efficient mix of anti-collagen antibodies for the generation of a collagen antibody induced arthritis (CAIA) mouse animal model. ModiQuest Research offers these CAIA antibodies to clients.</p> <p align="right"><span lang="EN-GB" style="FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=32" target="_blank"><u><font color="#810081">Please click here to go to our online shop directly</font></u></a>.</span></p> </td> <td valign="top" align="right"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=32" target="_blank"><img style="WIDTH: 152px; HEIGHT: 101px" height="105" alt="" src="downloads/Image/WebshopMQR.jpg" width="196"/></a> </td> </tr> </tbody> </table> </p> <p align="justify"> <table cellspacing="1" cellpadding="1" width="100%" border="0"> <tbody> <tr> <td><a href="downloads/download.php?id=42" target="_blank"><img style="WIDTH: 111px; HEIGHT: 152px" height="178" alt="" src="downloads/Image/CAIAspecsheet.jpg" width="161"/></a> </td> <td valign="top" align="left">Next to that under collaboration with third parties animal studies using these CAIA antibodies are offered by ModiQuest Research. For inquiries about full animal studies using the MQR-CAIA model please contact <a href="mailto:info@modiquestresearch.com?subject=CAIA%20full%20study%20inquiruies"><u><font color="#810081">ModiQuest Research</font></u></a> directly. <p>Please <a href="http://www.modiquestresearch.com/website/downloads/download.php?id=42" target="_blank"><u><font color="#810081">click here</font></u></a> for downloading a spec. sheet about the MQR-CAIA antibody model.</p> </td> </tr> </tbody> </table> </p> <p align="justify"> <table cellspacing="1" cellpadding="1" width="100%" border="0"> <tbody> <tr> <td valign="top" align="left"> <p>Collagen-induced arthritis is an antibody mediated disease.  Therefore, type II collagen specific antibodies can be used to induce arthritis in mice.</p> <p>Our mixture of type II collagen specific antibodies (2.6mg per animal) induces severe inflammation in the ankle and paws of DBA mice which resemble many aspects of arthritis.</p> <p>One of the biggest advantages of our monoclonal antibody-induced arthritis model is that severe arthritis is induced within 24-48 hours instead of the four weeks required to induce arthritis after immunization with type II collagen.</p> <p>ModiQuest Research recommends highly susceptible DBA/1 mice. Other strains may be used, however the amount of antibody cocktail required may vary. Thus, this model is ideal for rapidly screening therapeutics for the treatment of arthritis and to study the mechanisms involved in the development of arthritis.</p> </td> <td valign="top" align="right"> <p><img style="WIDTH: 152px" src="downloads/Image/Muisrechtop.jpg" width="152" alt=""/></p> <p> </p> <p> </p> </td> </tr> </tbody> </table> </p> <p align="justify"><br/> </p><font face="Verdana"></font><br/> <span lang="EN-US" style="FONT-SIZE: 10pt; mso-ansi-language: EN-US"> <div><strong>ModiQuest Research has a hightech facility to generate high producing primary cells and stable cell lines.</strong> </div> </span> <p align="justify"><span lang="EN-US" style="FONT-SIZE: 10pt; mso-ansi-language: EN-US"> <table cellspacing="1" cellpadding="1" width="100%" border="0"> <tbody> <tr> <td valign="top" align="left"><span> <div>ModiQuest Research uses a.o. AMAXA Nucleofection, </div> <div>high throughput ClonePix technology, </div> <div>and optimised ModiQuest Research vector systems.  </div> <div> </div> <div>ModiQuest Research has a large set of expression vectors available for the generation of stable recombinant antibody expressing cell lines using hybridomas, cDNA and/or sequences provided by the customer.  <br/> <br/> Various Mouse and Human isotypes as well as Chicken based recombinant (chimeric) antibody producing cell lines can be generated very efficiently. </div> </span></td> <td><font face="Verdana"> <img style="WIDTH: 142px; HEIGHT: 180px" height="197" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/clonepixb.JPG" width="158"/></font></td> </tr> <tr> <td valign="top" align="left" colspan="2"> <div>ModiQuest Research offers</div> <ul type="square"> <li><font face="Verdana">small scale production of recombinant antibodies </font></li> <li><font face="Verdana">fast, reliable and efficient generation of high producer stabel cell lines </font></li> <li><font face="Verdana">fully customized antibodies</font></li> </ul> <p align="justify"> <table cellspacing="1" cellpadding="1" width="50%" align="left" border="0"> <tbody> <tr> <td valign="top" align="left"> <p align="center"><font face="Verdana"> </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=55" target="_blank"><font face="Verdana"><img style="WIDTH: 151px; HEIGHT: 105px" height="130" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/HybridomaPPS.jpg" width="181"/></font></a></p> <p align="left"><a title="powerpoint slide show stable cell line technology" href="http://www.modiquestresearch.com/website/downloads/download.php?id=55" target="_blank"><u><font face="Verdana">Technology</font></u></a><font face="Verdana"> (PPS 8Mb)</font></p> </td> <td valign="top" align="left"> <p><font face="Verdana"> </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=35" target="_blank"><font face="Verdana"><img height="162" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Stable%20Antibody%20brochure.jpg" width="115"/></font></a></p> <p><font face="Verdana">For more information please </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=35" target="_blank"><u><font face="Verdana" color="#810081">click here</font></u></a><font face="Verdana"> (PDF 2Mb).</font></p> </td> </tr> </tbody> </table> </p> <p align="justify"><font face="Verdana"> </font></p> </td> </tr> </tbody> </table> </span></p><table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"><font face="Verdana"><strong>ModiQuest Research</strong> </font> <ul> <li> <div>has generated various unique <font color="#800000"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_48_49" target="_blank">propietary human and mouse anti-citrullin containing protein/peptide antibodies</a></font> for proteomic and diagnostic applications.</div> </li> <li> <div>Next to these propietary antibodies ModiQuest Research offers a set of <font color="#800000">unique antibodies</font> directed against known <font color="#800000"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26" target="_blank">human autoantigens</a></font> (apoptotic cleavage product of the <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26_27" target="_blank">hU1-70K protein</a>, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26_27" target="_blank">hU1-C protein</a>, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26_29" target="_blank">hJo-1 protein</a>, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26_38" target="_blank">hRpp20 protein</a>, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_26_39" target="_blank">hRrp4 protein</a>) and protein modifications potentially involved in human disease.</div> </li> <li> <div>Finally, ModiQuest Research offers anti human TNF antibodies, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_34" target="_blank"><u><font color="#0000ff">anti-Tag antibodies</font></u></a> (i.e. HIS, GST, EBFP), <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_35" target="_blank"><u><font color="#0000ff">anti collagen antibodies</font></u></a>, <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=21_36" target="_blank"><u><font color="#0000ff">anti IgY antibodies</font></u></a>, and antibodies specific for enzymes.</div> </li> </ul> </td> <td valign="top" align="right"><font face="Verdana"> <img alt="" src="downloads/Image/Tissue small.jpg"/></font></td> </tr> </tbody> </table> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"> <p align="justify"><a href="http://www.modiquestresearch.com/shop" target="_blank"><font face="Verdana"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/WebshopMQR.jpg"/></font></a></p> </td> <td valign="top" align="left"><font face="Verdana">For an overview of our antibodies and to purchase our antibodies online, </font><a href="http://www.modiquestresearch.com/shop" target="_blank"><font face="Verdana"><u><font color="#810081">please click here to go to our webshop</font></u>.</font></a></td> </tr> </tbody> </table> <p><font face="Verdana"> </font></p><p> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"> <p><strong><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=31" target="_blank"><img style="WIDTH: 161px; HEIGHT: 105px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/WebshopMQR.jpg" width="218" height="133"/></a></strong></p> </td> <td><strong>ModiQuest Research</strong> has developed a sensitive Antibody Based Assay to test for Peptidyl Arginine Deiminase (PAD) activity (ABAP). The ABAP is an Enzyme Linked-Immuno-Sorbent Assay (ELISA) for the determination of PAD enzyme activity in cell and tissue lysates. <p align="left"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=31" target="_blank"><u><font color="#810081"><strong>Please click here to go to our online shop directly</strong></font></u></a><strong>.</strong></p> <p align="left"><strong></strong></p> </td> </tr> </tbody> </table> </p> <p> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"> <p align="justify">PAD enzymes are transcriptional co-regulators that catalyze the calcium dependent conversion of specific arginine residues present in for instance histones to citrulline.  In diseases such as multiple sclerosis and rheumatoid arthritis (RA) these PAD enzymes seem to be dysregulated. For instance in RA these enzymes become active when they exit the cell in regions of joint inflammation where they deiminate arginines in proteins such as vimentin and fibrinogen. The level of PAD activity has been correlated with RA severity. </p> <p align="justify">The ABAP test is also suitable for determining PAD activity of purified recombinant PAD enzymes used in various bioassays. </p> <p align="justify"> </p> </td> <td valign="top" align="right"> <img style="WIDTH: 107px; HEIGHT: 158px" alt="" src="downloads/Image/Microscoop.jpg" width="116" height="158"/></td> </tr> </tbody> </table> </p> <p> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td><a href="downloads/download.php?id=41" target="_blank"><img style="WIDTH: 130px; HEIGHT: 170px" alt="" src="downloads/Image/ABAPspecsheet.jpg" width="142" height="170"/></a> </td> <td> <p align="justify">The <font color="#800000">MQR-ABAP</font> test is a powerful method to rapidly screen for PAD activity. Compared to currently used assays for PAD activity determination such as the DAMO BAEE conversion test the <font color="#800000">MQR-ABAP</font> assay is more robust, and at least 500 times more sensitive.  </p> <p align="justify">The ABAP kit consists of: 1) 96-well plate coated with Arginine containing peptides 2) A ModiQuest Research mouse PAD enzyme for activity calibration 3) a proprietary ModiQuest Research HRP-labelled monoclonal antibody specifically binding deiminated arginines. A detalied spec. sheet for the ABAP test can be downloaded by <a href="http://www.modiquestresearch.nl/shop/files/MQ17.101-96%20_ABAP_%20MQR.pdf" target="_blank"><u><font color="#0000ff">clicking here</font></u></a> (PDF 192Kb).</p> </td> </tr> </tbody> </table> </p><p><strong>Recombinant human and mouse Peptidyl Argininge Deiminase (PAD) enzymes.</strong></p> <p> <table cellspacing="1" cellpadding="1" width="100%" border="0"> <tbody> <tr> <td valign="top" align="left"> <p>ModiQuest Research provides purified recombinant human and mouse Peptidyl Arginine Deiminase (PAD) enzymes for research applications.</p> <p> </p> <p align="right"><a href="http://www.modiquestresearch.nl/shop/index.php?cPath=30" target="_blank">Please click here to go to our online shop directly</a></p> </td> <td> <a href="http://www.modiquestresearch.nl/shop/index.php?cPath=30" target="_blank"><img style="WIDTH: 158px; HEIGHT: 97px" height="93" alt="" src="downloads/Image/WebshopMQR.jpg" width="153"/></a></td> </tr> </tbody> </table> </p> <p> <table cellspacing="1" cellpadding="1" width="100%" border="0"> <tbody> <tr> <td><a href="downloads/download.php?id=36" target="_blank"><img style="WIDTH: 142px; HEIGHT: 214px" height="133" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Peptidyl%20brochure.jpg" width="156"/></a> </td> <td valign="top" align="left"> <p>PAD enzymes can be used for the deimination of cell lysates and proteins which will facilitate the proteomic analysis and identification of compounds that may be involved in the ontogeny of various autoimmune diseases like Rheumatoid Arthritis and Multiple Sclerosis.</p> <p> </p> <p>For more information please <a href="downloads/download.php?id=36" target="_blank">click here</a> (PDF 1.54Mb).</p> </td> </tr> </tbody> </table> <br/> </p><p><font face="Microsoft Sans Serif" size="1"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/logoBIO1.gif"/></font></p> <p>Bio2008, San Diego  </p> <p><strong>ModiQuest Research will be attending the 2008 BIO International Convention in San Diego coming June. Please, come visit us at booth 3135 at</strong> <strong>the Holland Pavilion or meet us using the partnering system!</strong></p> <p> </p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 7.1pt"><span lang="EN-GB" style="FONT-SIZE: 8pt; mso-ansi-language: EN-GB"></span></p> <table style="WIDTH: 407.55pt; mso-cellspacing: 0cm; mso-padding-alt: 0cm 0cm 0cm 0cm" cellspacing="0" cellpadding="0" width="543" border="0" class="MsoNormalTable"> <tbody> <tr style="mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <td style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 0.75pt; WIDTH: 6.2pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 0.75pt; BORDER-RIGHT-COLOR: #ece9d8" width="8"> <p style="TEXT-ALIGN: center" align="center"><span style="FONT-SIZE: 8.5pt; FONT-FAMILY: Arial"> <p> </p> </span></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> </td> <td style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 0.75pt; WIDTH: 389.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 0.75pt; BORDER-RIGHT-COLOR: #ece9d8" width="519"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB"><strong> <p style="LINE-HEIGHT: 12.75pt" align="justify"><span lang="EN-GB" style="FONT-SIZE: 18pt; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial">ModiQuest and ProteoNic announce </span><span lang="EN-GB" style="FONT-SIZE: 18pt; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial">collaboration</span></p> <p style="LINE-HEIGHT: 12.75pt" align="justify"><span lang="EN-GB" style="FONT-SIZE: 18pt; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial"><span style="FONT-SIZE: 9pt">Press Release - June 9, 2008</span></span></p> </strong></span> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 12.75pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB"><strong>Today ModiQuest and ProteoNic announce their collaboration on antibody expression in mammalian cell culture for use in diagnostic and therapeutic product development and manufacturing. ProteoNic will provide its expertise in construct design and protein expression optimization. ModiQuest will apply its proprietary vectors systems and expertise in high throughput production of high level expressing mammalian cell lines in combination with the UNic™ expression technology to manufacture its commercial antibodies in mammalian cell lines. </strong> <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">Both companies will be attending the upcoming BIO International Convention, to be held June 17-20 in </span><city></city> <place></place> <span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">San Diego</span> <span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">. Please visit us at our joint booth as part of the </span><city></city> <place></place> <span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">Holland</span> <span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">Pavilion (Booth 3135). <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">Jos Raats, Managing Director ModiQuest commented: “ModiQuest is most pleased with this current collaboration. Implementation of ProteoNic’s expression optimization cassettes will enable us to develop even better expression vectors and will allow faster progress of our therapeutic and diagnostic programs based on biologicals. Moreover, implementation of  ProteoNic’s UNic™ expression enhancement technology in our expression systems will enable us to offer fast production of even higher protein expressing cell lines for our own programs and as third party services to our customers.” <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">“This collaboration is another great opportunity to expand the validation and track record of the application of our UNic™ expression technology in mammalian cell culture”, ProteoNic CEO Victor Schut commented. “ModiQuest’s expertise in antibody expression strongly supports our technology development and experience in optimizing translation efficiency for a relevant group of commercial proteins commonly expressed in mammalian cell lines. Consequently, our collaboration will provide significant added value beneficial to the clients of ModiQuest. We are very pleased to have created a strong and mutually beneficial long term partnership supporting both scientific and commercial goals.” <p align="justify"><strong> </strong><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB"><strong>---------------------<br/> About ModiQuest </strong> <p align="justify"><span>ModiQuest is a young and dynamic biotech company, with a focus on high throughput generation of (recombinant) fully human and animal derived antibodies, especially for use as therapeutics and diagnostics in autoimmune diseases, infectious diseases and cancer. ModiQuest generates antibodies from both human and animal origin using a large panel of state-of-the-art technologies, such as B-cell selection and phage display applications.  For more information visit <a title="blocked::http://www.modiquestresearch.com/" href="http://www.modiquestresearch.com/"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><u><font color="#0000ff">www.modiquestresearch.com</font></u></span></a>  <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB"><strong>About ProteoNic  </strong> <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman"; mso-ansi-language: EN-GB">ProteoNic specializes in optimizing messenger RNA (translation machinery) applying its UNic™ expression technology to significantly boost upstream protein production in a wide range of biological host systems. ProteoNic aims at establishing the UNic™ technology as the state-of-the-art standard within the protein-based industries. This technology will result in significantly higher yields, improvements in quality and manufacturing flexibility in the context of lower production costs. To demonstrate this, ProteoNic has partnered with a number of companies active in various biotech applications. </span><span style="FONT-SIZE: 9pt; FONT-FAMILY: "Times New Roman""><a title="blocked::http://www.proteonic.nl/" href="http://www.proteonic.nl/"><span style="COLOR: black"><u>www.proteonic.nl</u></span></a></span> </p> </span></p> </span></p> </span></p> </span></p> </span></p> </span></p> </span></p> </td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #ece9d8; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #ece9d8"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"> </p> <p> </p> <p> </p> </td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #ece9d8; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #ece9d8"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"> </p> <p> </p> <p> </p> </td> </tr> </tbody> </table> <p><img style="WIDTH: 223px; HEIGHT: 73px" height="98" alt="" src="downloads/Image/MQRbio.jpg" width="278"/>    <font size="5"><strong>Discover Your Potential</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font face="Times New Roman"><span style="COLOR: black; FONT-FAMILY: Arial"><font face="Times New Roman"><span style="COLOR: black; FONT-FAMILY: Arial"><font face="Times New Roman"><span style="COLOR: black; FONT-FAMILY: Arial"><span lang="PT-BR" style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: "`Times New Roman`"; mso-ansi-language: PT-BR; mso-bidi-font-family: Arial"><a href="mailto:info@modiquestresearch.com"><u><span lang="NL" style="COLOR: blue; mso-ansi-language: NL"><font face="Times New Roman">info@modiquestresearch.com</font></span></u></a></span></span></font>                                 </span></font></span></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font face="Times New Roman"><span style="COLOR: black; FONT-FAMILY: Arial"><font face="Times New Roman"><span style="COLOR: black; FONT-FAMILY: Arial"></span></font></span></font><span lang="FR" style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: "`Times New Roman`"; mso-ansi-language: FR; mso-bidi-font-family: Arial; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><a href="http://www.modiquest.com/"><u><span lang="NL" style="COLOR: blue; mso-ansi-language: NL"><font face="Times New Roman">www.modiquestresearch.com</font></span></u></a></span><span style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: "`Times New Roman`"; mso-ansi-language: NL; mso-bidi-font-family: Arial; mso-fareast-font-family: `Times New Roman`; mso-fareast-language: NL; mso-bidi-language: AR-SA"><font face="Times New Roman"> </font></span></p><p><font face="Verdana"><strong>ModiQuest Research offers custom phage display recombinant antibody services.</strong>  </font></p> <p align="justify"> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" align="left"><font face="Verdana"><img style="WIDTH: 198px; HEIGHT: 131px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/labfoto014.jpg" width="198" height="137"/> </font></td> <td valign="top" align="left"> <div>The ModiQuest Research team has extensive experience in all aspects of phage display, including library construction from Human, Chicken, Rabbit, Llama, and Mouse B-cell repertoires (sdab, scfv, fab). </div> <div>ModiQuest Research can generate monoclonal recombinant antibodies in completely customized procedures and for client specified antigens. </div> <div>All recombinant monoclonal antibodies can be expressed in bacteria as scFv or Fab, or as full size fully human, fully mouse, fully chicken antibody formats, or in any chimeric antibody form required by the client, in mammalian cells. </div> <div> </div> <div>Both transient expression (up to 10 liter scale) and stable expression systems are provided. High producing stable cell lines can be efficiently generated using our <a href="http://www.modiquestresearch.com/website/show.php?id=9">automated stable cell line generation procedures</a>. </div> <p align="justify"><font face="Verdana">Various Human and animal derived antibody libraries are available (both naive or from patient groups or from immunized animal origin). Patient groups represented are i.e various autoimmune disease patients, Malaria patients, Chagas disease patients etc. Animal libraries are derived from animals immunized with human tissues and tumors, as wel as from animals immunized with various antigens (i.e. malaria parasites, cell lines, or protein antigens).</font></p> </td> <td valign="top" align="right"> <p><font face="Verdana"> <img style="WIDTH: 186px; HEIGHT: 130px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Labfoto_leeg.jpg" width="198" height="153"/></font></p> </td> </tr> </tbody> </table> </p> <p align="justify"><font face="Verdana"> </font></p><p> <table style="WIDTH: 365pt; BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" width="486" border="0" x:str=""> <colgroup><col style="WIDTH: 78pt; mso-width-source: userset; mso-width-alt: 3803" width="104"></col><col style="WIDTH: 162pt; mso-width-source: userset; mso-width-alt: 7899" width="216"></col><col style="WIDTH: 48pt" width="64"></col><col style="WIDTH: 77pt; mso-width-source: userset; mso-width-alt: 3730" width="102"></col></colgroup> <tbody> <tr style="HEIGHT: 23.25pt; mso-height-source: userset" height="31"> <td class="xl31" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; WIDTH: 365pt; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 23.25pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" width="486" colspan="4" height="31"> <p><strong><font size="5">Mouse monoclonals</font></strong></p> </td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><a href="http://www.modiquestresearch.nl/shop/" target="_blank">Please click here to go to our online shop directly</a></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt; mso-height-source: userset" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8; mso-ignore: colspan" colspan="2" height="17">Please click on catalogue no. for spec sheets</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" u1:num="38812"></td> <td style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Human RNase MRP complex</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=18" target="_blank"><u><font color="#0000ff"># MQ-1.201</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">hRpp20</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">1F11</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG2a</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Human Exosome complex</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=22" target="_blank"><u><font color="#0000ff"># MQ-2.103</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">hRrp4</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">15B3</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Human collagen I</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=21" target="_blank"><u><font color="#0000ff"># MQ-3.101</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">hcol I</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">2G8</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgM</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=23" target="_blank"><u><font color="#0000ff"># MQ-3.102</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">hcol I</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">9D7</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 15pt" height="20"> <td class="xl27" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 15pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="20"></td> <td class="xl27" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl27" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl27" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl29" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Bovine collagen II</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=17" target="_blank"><u><font color="#0000ff"># MQ-4.116</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">m/b Col II</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">12F6</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl29" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17" u1:str="Collagenase "><strong>Collagenase<span style="mso-spacerun: yes"> </span></strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-TOP-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=16" target="_blank"><u><font color="#0000ff"># MQ-5.101</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">collagenase</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">1D2</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG2b</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Enhanced Blue Fluorescent Protein</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent" bordercolor="#000000">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent" bordercolor="#000000">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=13" target="_blank"><u><font color="#0000ff"># MQ-6.102</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">EBFP</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">3A6</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=15" target="_blank"><u><font color="#0000ff"># MQ-6.103</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">EBFP</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">6G9</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=14" target="_blank"><u><font color="#810081"># MQ-6.104</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">EBFP</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">7F10</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17" u1:str="Glutathionine S-transferase "><strong>Glutathionine S-transferase<span style="mso-spacerun: yes"> </span></strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=12" target="_blank"><u><font color="#0000ff"># MQ-7.102</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">GST</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">2A9</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG2a</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Histidine Tag</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=11" target="_blank"><u><font color="#0000ff"># MQ-8.101</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">His 6x</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">5B12</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG2b</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 14.25pt; mso-height-source: userset" height="19"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 14.25pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="19"><strong>Mouse protein tyrosine<font class="font7"><sup> </sup></font><font class="font6">phosphatase PTP-BL PDZ domain 2</font></strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="http://www.modiquestresearch.nl/website/downloads/download.php?id=10" target="_blank"><u><font color="#810081"># MQ-9.102</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">mPDZ2</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">4B6</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG1</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" colspan="4" height="17"><strong>Mouse protein tyrosine phosphatase gene Ptprr</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl24" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT-COLOR: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl26" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8" height="17"><a href="downloads/download.php?id=40" target="_blank"><u><font color="#810081"># MQ-10.101</font></u></a></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">PTPBR7, PTP-SL, PTPPBS<font class="font8" face="Symbol">g, </font><font class="font5">STEP</font></td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">6A6</td> <td class="xl25" style="BORDER-LEFT-COLOR: #d4d0c8; BORDER-BOTTOM-COLOR: #d4d0c8; BORDER-TOP-COLOR: #d4d0c8; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #d4d0c8">IgG</td> </tr> </tbody> </table> </p><div><font color="#000000"></font></div> <br/> <div><font color="#000000">Modiquest Research offers</font></div> <div> </div> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="justify"><strong></strong></p> <p style="MARGIN: 0cm 0cm 0pt" align="justify"> <table border="0" cellspacing="1" cellpadding="1" width="100%"> <tbody> <tr> <td valign="top" colspan="5" align="left"> <p><strong>Efficient and excellent quality hybridoma generation</strong> </p> </td> </tr> <tr> <td valign="top" colspan="3" align="left"> </td> <td><font color="#000000"></font> <ul dir="ltr"> <li> <div><font color="#000000">automated <strong>high throughput</strong> cell screening facilities (ClonePix technology)</font></div> </li> <li> <div><font color="#000000">very efficient <strong>electro-fusion</strong></font></div> </li> <li> <div><font color="#000000"><strong>proprietary B-cell selection</strong></font><font color="#000000"> and culture technology</font> </div> </li> </ul> </td> <td valign="middle" align="right"> <img style="WIDTH: 198px; HEIGHT: 152px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Clonepix(1).JPG" width="198" height="161"/></td> </tr> <tr> <td valign="top" colspan="3" align="left"></td> <td colspan="2"> <p align="justify">Once hybridoma cell lines are developed, we can produce monoclonal antibodies suitable for various types of standard laboratory assays in a small scale bioreactor (CL1000 Integra).  </p> </td> </tr> <tr> <td valign="top" colspan="3" align="left"> </td> <td colspan="2"> </td> </tr> <tr> <td valign="top" colspan="3" align="left"> </td> <td colspan="2"> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="left">Learn more about our ClonePix technology </p> <p style="MARGIN: 0cm 0cm 0pt" align="left"> <table border="0" cellspacing="1" cellpadding="1" width="70%"> <tbody> <tr> <td valign="top" align="center"> <p align="left"><a title="powerpoint slide show hybridoma technology" href="http://www.modiquestresearch.com/website/downloads/download.php?id=58" target="_blank"><img style="WIDTH: 151px; HEIGHT: 105px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/HybridomaPPS.jpg" width="181" height="130"/></a></p> <p align="left"><a title="powerpoint slide show hybridoma technology" href="http://www.modiquestresearch.com/website/downloads/download.php?id=58" target="_blank"><u>Technology</u></a> (PPS 2Mb)</p> </td> <td valign="top" align="center"> <p align="left"><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=59" target="_blank"><img style="WIDTH: 94px; HEIGHT: 110px" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Hybridomafactsheet(1).jpg" width="190" height="318"/></a></p> <p align="left"><a href="javascript:void(0);/*1221073069156*/"><u><font color="#800080">Protocol and cost</font></u>  (PDF 155Kb)</a></p> </td> </tr> </tbody> </table> </p> </td> </tr> </tbody> </table> </p> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="left"> </p> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="left"> </p> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="left"> </p> <p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="left"> </p><p> <table style="WIDTH: 365pt; BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" width="486" border="0" x:str=""> <colgroup><col style="WIDTH: 78pt; mso-width-source: userset; mso-width-alt: 3803" width="104"></col><col style="WIDTH: 162pt; mso-width-source: userset; mso-width-alt: 7899" width="216"></col><col style="WIDTH: 48pt" width="64"></col><col style="WIDTH: 77pt; mso-width-source: userset; mso-width-alt: 3730" width="102"></col></colgroup> <tbody> <tr style="HEIGHT: 23.25pt" height="31"> <td class="xl26" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 365pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 23.25pt; BACKGROUND-COLOR: transparent" width="486" colspan="4" height="31"><strong><font size="5">Human monoclonals</font></strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" colspan="4" height="17"><a href="http://www.modiquestresearch.com/shop " target="_blank">Please click here to go to our online shop directly</a></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17"></td> <td style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> <td style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> <td style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent; mso-ignore: colspan" colspan="2" height="17">Please click on catalogue no. for spec sheets</td> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" u1:num="38812"></td> <td style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17"></td> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> <td class="xl25" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> <td style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent"></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext 0.5pt solid; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQ-12.103</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">unknown</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102" x:str="IgG2/kappa "><font color="#339966">IgG2/kappa<span style="mso-spacerun: yes"> </span></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl24" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"></font></td> <td class="xl24" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966"></font></td> <td class="xl24" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl24" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl29" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" colspan="4" height="17"><strong>Anti citrulline cotaining peptide antibodies</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQR2.101</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">Citrullinated<span style="mso-spacerun: yes">  </span>Fibrinogen</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQR2.102</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">Citrullinated<span style="mso-spacerun: yes">  </span>Fibrinogen</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQR2.104</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">Citrullinated<span style="mso-spacerun: yes">  </span>Fibrinogen</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 13.5pt; mso-height-source: userset" height="18"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 13.5pt; BACKGROUND-COLOR: transparent" width="104" height="18"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl29" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" colspan="4" height="17"><strong>Anti human auto-antigen antibodies</strong></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext 0.5pt solid; BORDER-BOTTOM: windowtext 0.5pt solid; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" height="17">Catalogue no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Antigen</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Clone no.</td> <td class="xl28" style="BORDER-RIGHT: windowtext 0.5pt solid; BORDER-TOP: windowtext; BORDER-LEFT: windowtext; BORDER-BOTTOM: windowtext 0.5pt solid; BACKGROUND-COLOR: transparent">Isotype</td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQR 2.301</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">hU1-C protein</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"># MQR 2.401</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">hJo-1 protein</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 12.75pt" height="17"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 12.75pt; BACKGROUND-COLOR: transparent" width="104" height="17"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"><font color="#339966"></font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"><font color="#339966"></font></td> </tr> <tr style="HEIGHT: 25.5pt" height="34"> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 78pt; BORDER-BOTTOM: #d4d0c8; HEIGHT: 25.5pt; BACKGROUND-COLOR: transparent" width="104" height="34"><font color="#339966"># MQR 2.201</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 162pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="216"><font color="#339966">hU1-70K protein, 40 kD apoptotic cleavage product</font></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 48pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="64"></td> <td class="xl27" style="BORDER-RIGHT: #d4d0c8; BORDER-TOP: #d4d0c8; BORDER-LEFT: #d4d0c8; WIDTH: 77pt; BORDER-BOTTOM: #d4d0c8; BACKGROUND-COLOR: transparent" width="102"></td> </tr> </tbody> </table> </p><p><font face="Microsoft Sans Serif" size="1"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/logoBIO1.gif"/></font></p> <p>Bio2007, Boston, May 5 - </p> <p><strong>ModiQuest Research will be attending the 2007 BIO International Convention in Boston starting coming May 7th. Please, come visit us at booth 2633 at the Holland Pavilion or meet us using the partnering system!</strong></p> <p> </p><p>Download <strong>ModiQuest Research</strong> brochures.</p> <p> <table cellspacing="3" cellpadding="2" width="100%" border="0"> <tbody> <tr> <td valign="top" align="left"> <p align="left"><a title="Corporate overview (2MB)" href="downloads/download.php?id=64" target="_blank"><img style="WIDTH: 198px; HEIGHT: 254px" height="273" alt="" src="downloads/Image/MQR Corporate Overview brochure.jpg" width="166"/></a></p> </td> <td valign="top" align="left"> <p align="left"><a href="downloads/download.php?id=39" target="_blank"><img style="WIDTH: 183px; HEIGHT: 257px" height="274" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Recombinant%20Antibody%20brochure.jpg" width="166"/></a></p> </td> <td valign="top" align="left"> <a href="downloads/download.php?id=34" target="_blank"><img style="WIDTH: 174px; HEIGHT: 253px" height="272" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Collagen%20Antibody%20brochure.jpg" width="166"/></a></td> </tr> <tr> <td valign="top"> <p align="left">  <a title="Corporate overview (2MB)" href="downloads/download.php?id=64" target="_blank"><u><font color="#810081" size="1">Corporate overview</font></u></a><font size="1"> (2MB)</font></p> </td> <td valign="top"> <p align="center"><font size="1"> </font><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=39" target="_blank"><font size="1">(Recombinant) antibody services</font></a><font size="1"> (2MB)</font></p> </td> <td> <p align="center"><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=34" target="_blank"><font size="1">Collagen Antibody Induced Arthritis Mouse Model</font></a><font size="1"> (2MB)</font></p> <p align="center"> </p> </td> </tr> <tr> <td valign="top" align="left"> <p align="left"> <a href="downloads/download.php?id=35" target="_blank"><img style="WIDTH: 196px; HEIGHT: 250px" height="270" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Stable%20Antibody%20brochure.jpg" width="182"/></a></p> </td> <td valign="top" align="left"> <p align="left"> <a href="downloads/download.php?id=36" target="_blank"><img style="WIDTH: 167px; HEIGHT: 248px" height="273" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Peptidyl%20brochure.jpg" width="167"/></a></p> </td> <td valign="top" align="left"> <p align="left"> <a href="downloads/download.php?id=37" target="_blank"><img style="WIDTH: 165px; HEIGHT: 246px" height="271" alt="" src="http://www.modiquestresearch.com/website/downloads/Image/MQR%20Proprietary%20brochure.jpg" width="165"/></a></p> </td> </tr> <tr> <td> <p align="center"><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=35" target="_blank"><font size="1">Stable recombinant antibody producing cell line generation</font></a><font size="1"> (2MB)</font></p> </td> <td> <p align="center"><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=36" target="_blank"><font size="1">Peptidyl Arginine Deiminase (PAD) enzyme products</font></a><font size="1"> (2MB)</font></p> </td> <td> <p align="center"><a href="http://www.modiquestresearch.com/website/downloads/download.php?id=37" target="_blank"><font size="1">Proprietary anti citrulline antibodies</font></a><font size="1"> (2MB)</font></p> </td> </tr> </tbody> </table> </p><p>Download <strong>ModiQuest Research</strong> company flyers.</p> <p><strong></strong></p> <p><strong>Click on the language you require:</strong> </p> <p> <table border="0" cellspacing="10" cellpadding="10" width="300"> <tbody> <tr> <td> <a title="Dutch Company Flyer" href="http://www.modiquestresearch.com/website/downloads/download.php?id=49" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Flag%20NL%2072dpi%203cm.jpg" width="40" height="20"/>Dutch</a></td> <td> <a title="Chinese Company Flyer" href="downloads/download.php?id=53" target="_blank"><img alt="" src="downloads/Image/Flag CN 72dpi 3cm.jpg" width="40" height="20"/>Chinese</a></td> </tr> <tr> <td> <a title="German Company Flyer" href="http://www.modiquestresearch.com/website/downloads/download.php?id=51" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Flag%20DU%2072dpi%203cm.jpg" width="40" height="20"/>German</a></td> <td> <a title="Japanese Company Flyer" href="downloads/download.php?id=54" target="_blank"><img alt="" src="downloads/Image/Flag JP 72dpi 3cm.jpg" width="40" height="20"/>Japanese</a></td> </tr> <tr> <td> <a title="English Company Flyer" href="downloads/download.php?id=50" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Flag%20UK%2072dpi%203cm.jpg" width="40" height="20"/>English</a></td> <td> <a title="French Company Flyer" href="downloads/download.php?id=56" target="_blank"><img alt="" src="downloads/Image/Flag FR 72dpi 3cm.jpg" width="40" height="20"/>French</a></td> </tr> <tr> <td> <a title="Spanish Company Flyer" href="http://www.modiquestresearch.com/website/downloads/download.php?id=52" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/Flag%20SP%2072dpi%203cm.jpg" width="40" height="20"/>Spanish </a></td> <td> <a title="Italian Company Flyer" href="downloads/download.php?id=57" target="_blank"><img alt="" src="downloads/Image/Flag IT 72dpi 3cm(1).jpg" width="40" height="20"/>Italian</a></td> </tr> </tbody> </table> </p> <p> </p> <p><a title="Dutch Company Flyer" href="downloads/download.php?id=49" target="_blank"></a></p> <p><a title="German Company Flyer" href="downloads/download.php?id=51" target="_blank"></a></p> <p><a title="English Company Flyer" href="downloads/download.php?id=50" target="_blank"></a></p> <p><a title="English Company Flyer" href="downloads/download.php?id=48" target="_blank"></a></p> <p><a title="Spanish Company Flyer" href="downloads/download.php?id=52" target="_blank"></a></p><p> <table style="WIDTH: 407.55pt; mso-cellspacing: 0cm; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 0cm 0cm 0cm" cellspacing="0" cellpadding="0" width="543" border="0" class="MsoNormalTable"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; BORDER-LEFT-COLOR: #f0f0f0; BACKGROUND: white; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0.75pt; WIDTH: 389.15pt; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0.75pt; BORDER-RIGHT-COLOR: #f0f0f0" width="519"> <p style="TEXT-ALIGN: justify" align="justify"><span lang="EN-GB" style="FONT-SIZE: 16pt; mso-ansi-language: EN-GB"><font face="Times New Roman">ModiQuest and Pepscan to collaborate on the identification of "me-too" monoclonal antibodies and monoclonal antibodies against intractable targets <p align="justify"> <font face="Times New Roman"><b><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB">Press Release - June 12, 2008</span></b><span lang="EN-GB" style="mso-ansi-language: EN-GB"> <p align="justify"> <font face="Times New Roman"><span><strong>Nijmegen and Lelystad, The . ModiQuest Research and Pepscan announced today the start of a research collaboration to identify human and animal derived "me-too" monoclonal antibodies and monoclonal antibodies against intractable disease targets. These targets include membrane proteins like GPCRs and ion channels. </strong> <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB"><font face="Times New Roman">Using its proprietary CLIPS™ technology Pepscan will generate functional mimics of intractable targets. <span style="FONT-WEIGHT: normal">ModiQuest will apply various methods like proprietary B-cell selection and cloning, or phage display to generate </span>potent functional <span style="FONT-WEIGHT: normal">antibodies against</span> mimics of the essential parts of such intractable targets. <p align="justify"><font face="Times New Roman"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB">Both companies will be attending the upcoming BIO International Convention, to be held June 17-<metricconverter w:st="on" productid="20 in"></metricconverter>20 in <place w:st="on"></place> <city w:st="on"></city>San Diego. Please visit us at our booth as part of the Holland</span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"> </font></span><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB">Pavilion (Booth 3135). </span><span lang="EN-GB" style="mso-ansi-language: EN-GB"> <p align="justify"><font face="Times New Roman"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB">Jos Raats</span> <span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB">, Managing Director of ModiQuest commented: “ModiQuest is very pleased with this collaboration. Combining the exceptional strength of Pepscan’s CLIPS<sup>TM </sup>technology and ModiQuest’s unique combination of antibody-generating technologies (fully human or animal derived), will allow for the generation of novel therapeutic and diagnostic antibodies, for application in the fields of autoimmune diseases, infectious diseases, and cancer”. <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB"><font face="Times New Roman">Rob Meloen, CSO of Pepscan Therapeutics comments: “I am excited about this collaboration with ModiQuest as it will give Pepscan access to monoclonal antibody technologies and capabilities, thus expanding our product scope beyond therapeutic vaccines into monoclonal antibodies”. <p align="justify"> <font face="Times New Roman"><span><font size="3"> </font>---------------------</span></font><span><br/> <font face="Times New Roman"><strong>About ModiQuest Research</strong> </font> <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB"><font face="Times New Roman">ModiQuest Research is a young and dynamic biotech company, with a focus on high throughput generation of (recombinant) fully human and animal derived antibodies, especially for use as therapeutics and diagnostics in autoimmune diseases, infectious diseases and cancer. ModiQuest Research generates antibodies from both human and animal origin using a large panel of state-of-the-art technologies, such as B-cell selection and phage display applications.  For more information please visit: </font><a title="blocked::http://www.modiquestresearch.com/" href="http://www.modiquestresearch.com/"><span style="COLOR: windowtext"><u><font face="Times New Roman">www.modiquestresearch.com</font></u></span></a><font face="Times New Roman">  </font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"> <p align="justify"><font face="Times New Roman"><span><strong>About Pepscan</strong>  <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 9pt; mso-ansi-language: EN-GB"><font face="Times New Roman">Pepscan Therapeutics is a product focused immunotherapy company based in the <place w:st="on"></place> . It has developed a pipeline of therapeutic vaccine and antibody programs of which the most advanced is in Phase II clinical testing. Pepscan’s proprietary CLIPS™ technology has been proven to yield functional antibodies reactive with a range of complex proteins, including GPCRs.  For more information please visit: </font><a href="http://www.modiquestresearch.com/AppData/Local/Microsoft/Windows/Temporary%20Internet%20Files/Content.Outlook/5NWBFHL2/www.pepscan.com"><span style="COLOR: windowtext"><u><font face="Times New Roman">www.pepscan.com</font></u></span></a></span> </p> </span></font></p> </span></p> </span></p> </font></span></p> </span></font></p> </span></font></p> </font></span></p> </span></font></p> </span></font></p> </font></span></p> </td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #f0f0f0; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #f0f0f0"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Times New Roman"> </font></font></span></p> </td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #f0f0f0; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #f0f0f0"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Times New Roman"> </font></font></span></p> </td> </tr> <tr style="mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <td style="PADDING-RIGHT: 0.75pt; PADDING-LEFT: 0.75pt; BORDER-LEFT-COLOR: #f0f0f0; BACKGROUND: white; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0.75pt; WIDTH: 389.15pt; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0.75pt; BORDER-RIGHT-COLOR: #f0f0f0" width="519"><span lang="EN-GB" style="FONT-SIZE: 16pt; mso-ansi-language: EN-GB"> <p align="justify"><img style="WIDTH: 236px; HEIGHT: 69px" height="69" alt="" src="downloads/Image/MQRbio.jpg" width="236" align="middle"/>                 <img alt="" src="downloads/Image/Pepscan Therapeutics logoBJPG.jpg"/></p> <p align="justify"><span lang="EN-GB" style="FONT-SIZE: 18pt; COLOR: black; FONT-FAMILY: `Arial`,`sans-serif`; mso-ansi-language: EN-GB"><strong>Discover Your Potential</strong></span></p> </span></td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #f0f0f0; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #f0f0f0"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="mso-ansi-language: EN-GB"> <p><font face="Times New Roman" size="3"> </font></p> </span></p> <p> </p> </td> <td style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; BORDER-LEFT-COLOR: #f0f0f0; BORDER-BOTTOM-COLOR: #f0f0f0; PADDING-BOTTOM: 0cm; BORDER-TOP-COLOR: #f0f0f0; PADDING-TOP: 0cm; BACKGROUND-COLOR: transparent; BORDER-RIGHT-COLOR: #f0f0f0"> <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="mso-ansi-language: EN-GB"> <p><font face="Times New Roman" size="3"> </font></p> </span></p> <p> </p> </td> </tr> </tbody> </table> </p><p><strong><img alt="" src="downloads/Image/MQRbio.jpg"/></strong></p> <p><strong>ModiQuest Research sponsored and participated in the <a href="http://www.visiongain.com/Conference.aspx?cid=160" target="_blank">"5th Annual Monoclonal Antibodies; Advancing therapeutic antibody development and production, London, March 2009".</a> </strong></p> <p><strong></strong></p> <p><strong> <p><br/> </p> </strong></p> <p> </p> <p> </p> <p> </p> <p> </p><p><strong><font size="4"><img alt="" src="downloads/Image/logo_tradeshow.gif"/></font></strong></p> <p><strong><font size="4">Biotechnica 2008, Hannover</font></strong>  </p> <p><strong>ModiQuest Research will be attending the 2008 Biotechnica in Hannover, Germany, 7-9 October 2008. </strong></p> <p><strong>Please, come visit us at Stand G12, in Hall 9!</strong></p> <p><strong>For pdf download of our <a title="ModiQuest Research Company Profile" href="downloads/download.php?id=63" target="_blank">company profile click here</a>.</strong></p> <p><strong>For pdf download of our company for <a title="ModiQuest Research Partnering Profile" href="downloads/download.php?id=62" target="_blank">partnering options please click here</a>. </strong></p> <p><strong></strong></p> <p><strong></strong></p> <p> </p><p><font size="3"><strong>Scottish Bio Industry and the Dutch BioFarmind </strong></font></p> <p><font size="3"><strong>Partnering event 10-11 November 2008</strong></font></p> <p><strong>ModiQuest Research</strong> Participates in this partnering event supported by: </p> <div class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="FONT-SIZE: 11pt; FONT-FAMILY: "Bookman Old Style"; mso-ansi-language: EN-GB"><font face="Arial" size="2">Trade & Investment, </font> <div class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="FONT-SIZE: 11pt; FONT-FAMILY: "Bookman Old Style"; mso-ansi-language: EN-GB"><font face="Arial" size="2">SenterNovem, </font> <div class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="FONT-SIZE: 11pt; FONT-FAMILY: "Bookman Old Style"; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial"><font face="Arial" size="2">BioFarmind The Agency for International Business and Cooperation (EVD) Holland, </font> <div class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"> <div class="MsoNormal" style="MARGIN: 0cm 0cm 0pt"><span lang="EN-GB" style="FONT-SIZE: 11pt; FONT-FAMILY: "Bookman Old Style"; mso-ansi-language: EN-GB"><font face="Arial" size="2">BioIndustry Association (BIA),</font></span></div> <font face="Arial">Scottish office of the Association of the British Pharmaceutical Industry (ABPI)</font></div> </span></div> </span></div> </span></div> <div> </div><p><font face="Microsoft Sans Serif" size="1">                                                                                                 </font></p> <p> <table cellspacing="1" cellpadding="1" width="100%" border="1"> <tbody> <tr> <td> <a href="http://bio2009.bdmetrics.com/CDT-6134563/ModiQuest-Research-B-V-/Details.aspx" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/logoBIO1.gif"/></a></td> <td valign="middle" align="right"> <a href="downloads/download.php?id=65" target="_blank"><img alt="" src="http://www.modiquestresearch.com/website/downloads/Image/0905nature%20bitotech_thumb.png" align="textTop"/></a></td> </tr> <tr> <td> Bio2009, Atlanta</td> <td align="right"> Special Nature Biotech</td> </tr> <tr> <td colspan="2"><strong>ModiQuest Research will be attending the 2009 BIO International Convention in Atlanta coming May. Please, come visit us at booth <font size="2"><span lang="EN-GB" style="FONT-SIZE: 11pt; FONT-FAMILY: Calibri; mso-fareast-font-family: `Times New Roman`; mso-bidi-font-family: `Times New Roman`; mso-ansi-language: EN-GB; mso-fareast-language: NL; mso-bidi-language: AR-SA">4649</span> at</font></strong> <strong>the Holland Pavilion or meet us using the partnering system!</strong></td> </tr> </tbody> </table> </p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"> <p><font size="3"><strong></strong></font></p> <p><strong><font size="4">Hybridoma generation</font></strong></p> <p align="justify"><font size="3">ModiQuest Research offers high-throughput generation of hybridoma cell lines. Our team uses an in-house developed highly efficient electrofusion technology. This unique technology is linked to </font><font size="3">the ClonePix-FL technology to perform high-throughput automated screening and collection of antigen specific clones. </font></p> <p><font size="3">This innovative approach:</font></p> <ul> <li><font size="3">eliminates labour intensive / time consuming downstream screening and subcloning by limited dilution</font> </li> </ul> <ul> <li><font size="3">reduces the numbers of animals needed to generate hybridomas</font> </li> </ul> <ul> <li><font size="3"><font face="Calibri"><font size="3">works for a broad range of antigens</font></font></font></li> </ul> <ul> <li><font size="3"><font face="Calibri"><font size="3">delivers fast results; 7-14 days to isolate selected clones</font></font></font></li> </ul> </font></font> <p align="justify"><font face="Calibri" size="3">Using this approach ModiQuest Research can screen large numbers of hybridomas in a high-throughput manner, hereby improving the success rate and production levels of the selected hybridomas. </font></p> </span><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Electrofusion</font></strong> <p><font size="3">By combining our highly efficient proprietary electrofusion method with the ClonePix-FL technology, our team can rapidly generate high quality mouse and rat hybridomas.  </font></p> <p><font size="3">An outline of the approach and time lines is as follows:</font></p> <ul> <li><font size="3">Phase 1  - Immunisation, approximately 60 days </font></li> </ul> <ul> <li><font size="3"><font face="Calibri"><font size="3">Phase 2  - Direct fusion plus automated cell screening and picking with ClonePixFL, 7-14 days</font></font></font>  </li> </ul> <ul> <li><font size="3"><font face="Calibri"><font size="3">Phase 3  - Subcloning and antibody characterization, approximately 4 weeks</font></font></font> </li> </ul> <ul> <li><font face="Calibri" size="3">Phase 4  - Bioreactor (Integra CL1000) antibody production, 6-8 weeks</font> </li> </ul> </font></font> <p><font face="Calibri" size="3">ModiQuest Research guarantees to deliver positive clones, using its standard protocols.</font></p> </span></p> <p> </p> <p> </p><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">B-cell selection and electrofusion</font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">For  difficult or poorly<font size="3"><span lang="EN-GB" style="FONT-SIZE: 11pt; LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; mso-ansi-language: EN-GB; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA"> immunogenic antigens we recommend our <a href="http://www.modiquestresearch.com/website/index.php?id=7"><span style="COLOR: windowtext; TEXT-DECORATION: none; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial; mso-bidi-font-weight: bold; text-underline: none">antigen B-cell selection technology</span></a>. T<span lang="EN-GB" style="FONT-SIZE: 11pt; LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; mso-ansi-language: EN-GB; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA">his technology allows for the selection of rare antigen-specific B-cells from immunised animals or humans with an active B-cell response.<span style="mso-spacerun: yes">  </span></span></span></font> <p align="justify"><font size="3"><span lang="EN-GB" style="FONT-SIZE: 11pt; LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; mso-ansi-language: EN-GB; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA"><span lang="EN-GB" style="FONT-SIZE: 11pt; LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; mso-ansi-language: EN-GB; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA"><span style="mso-spacerun: yes"></span>Using mice, the selected B-cells are subsequently used to generate hybridomas. For other species (rabbit, lama, and human), the antibody-encoding cDNA from antigen-specific B-cells is cloned and expressed in our proprietary <a href="show.php?id=52"><u><font color="#0000ff">recombinant antibody expression system</font></u></a>.</span></span></font></p> <p align="justify"><font size="3">This approach can be used for:</font></p> <ul> <li><font size="3">highly efficient hybridoma generation</font> </li> </ul> <ul> <li><font size="3"><font face="Calibri"><font size="3">cloning and expression of antibody encoding cDNA from antigen-specific B-cells</font></font></font> </li> </ul> <p><span lang="EN-GB" style="FONT-SIZE: 11pt; COLOR: windowtext; FONT-FAMILY: Calibri; mso-ansi-language: EN-GB">As such, this approach has a higher efficiency than standard hybridoma generation.</span></p> </font></font></span></p> <p> </p> <p> </p><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Phage display</font>  </strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">ModiQuest Research has extensive experience in phage display technology. Using our </font></font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">phage display methods </font></font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">in combination with our recombinant antibody expression technology, we can generate fully human or animal derived antibodies against virtually any target. </font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">ModiQuest Research has various human and animal derived antibody libraries available. Our animal libraries are derived from naive animals, animals immunized with human tissues or tumors, as well as from animals immunized with various antigens. Our h</font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">uman libraries are derived from:</font></span></p> <ul> <li> <div><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">naive individuals</font></span></div> </li> </ul> <ul> <li> <div><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">patients with various autoimmune disorders</font></span></div> </li> </ul> <ul> <li> <div><span lang="EN-GB" style="mso-ansi-language: EN-GB"></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">patients with Malaria</font></span></div> </li> </ul> <ul> <li> <div><span lang="EN-GB" style="mso-ansi-language: EN-GB"></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">patients with Chagas disease</font></span></div> </li> </ul> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">In addition ModiQuest Research is able to generate new animal or human derived libraries on request. </font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">After selection of the antigen specific antibody with the requested properties, the cDNA sequence can be cloned in our proprietary <a href="show.php?id=55">eukaryotic antibody expression vector set</a> to generate recombinant monoclonal antibodies. Antibodies of various species and isotypes can be generated.</font></span></p><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">B-cell selection and cloning</font></strong>  </font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">For species other than mice and rats (e.g. rabbits, lamas, and humans), the antibody-encoding cDNA from antigen-specific B-cells can be cloned and expressed in a recombinant antibody format.</font></font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"> <font size="3"> <p align="justify"><font size="3">ModiQuest Research has a large set of <a href="show.php?id=55">antibody expression vectors</a> allowing the expression of various human and mouse antibody isotypes in CHO or HEK-293 cells. Antibodies can be produced in continuous culture, following stable cell line generation or batch-wise from transiently transfected mammalian cells. </font></p> </font></font></font></span></p> <p> </p> <p> </p> <p> </p><p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="4"><strong>Antibody sequencing</strong></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">Antibody encoding cDNA obtained via phage display technology or provided by the client can be cloned and expressed in a recombinant antibody system.  </font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">ModiQuest Research has a large set of <a href="show.php?id=55">antibody expression vectors</a> allowing the expression of various recombinant isotypes in CHO or HEK-293 cells. Both transient and stable expression systems are provided. Stable, high level, antibody expressing cell lines can be efficiently generated using our </font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">stable cell line generation procedures.</font></span></p><p><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Recombinant antibody generation</font></strong>  <p align="justify"><font size="3">ModiQuest Research offers custom recombinant antibody services for antibody encoding cDNA originating from phage display, hybridoma, and B-cell cloning technologies. Recombinant antibodies can be expressed in bacteria in scFv, scFv-CL, and Fab formats. Fully human, mouse, or chicken antibodies of different <a href="show.php?id=55"><u><font color="#810081">isotypes</font></u></a>, or any chimeric antibody required by the client can be expressed in mammalian cell lines such as CHO and HEK-293. </font></p> <p><font size="3" face="Calibri">Our team uses the ClonePix-FL technology for efficient high-throughput (sub)cloning of stable cell lines expressing recombinant antibodies. </font>  </p> <p align="justify"><font size="3">ModiQuest Research provides:</font></p> <ul> <li><font size="3"><font face="Calibri"><font size="3">antibody generation against virtually any target (provided as peptide, protein, or as sequence only)</font></font></font></li>   <li><font size="3"><font face="Calibri"><font size="3">antibody synthesis from (customer provided) amino acid or cDNA sequences</font></font></font></li>   <li><font size="3"><font face="Calibri"><font size="3">stable, high-level, antibody producing cell lines (CHO or HEK-293)</font></font></font></li>   <li><font size="3">lab-scale transient recombinant antibody production in mammalian cells</font></li>   <li><font size="3">lab-scale recombinant antibody production using stable mammalian cell lines</font></li> </ul> </font></font></span></p> <p> </p><p><span style="LINE-HEIGHT: 115%; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><font size="4" face="Calibri"><span style="mso-spacerun: yes"><strong>Available isotypes</strong></span></font></span></p> <p><span style="LINE-HEIGHT: 115%; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><font face="Calibri"><span style="mso-spacerun: yes"></span></font></span></p> <p><span style="LINE-HEIGHT: 115%; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><font face="Calibri"><span style="mso-spacerun: yes">ModiQuest Research offers antibody expression vectors for:</span></font></span></p> <ul> <li><span lang="EN-US"><font size="3" face="Calibri">Human IgA1, IgG1, IgG3, IgG4 and IgM isotypes (both Kappa & Lambda)</font></span> </li> <li><span lang="EN-US"></span><span lang="EN-US"><font size="3" face="Calibri">Mouse IgG1, IgG2a, IgG2b and IgG3 isotypes (both Kappa & Lambda)</font></span> </li> <li><span lang="EN-US"><font size="3" face="Calibri">Chicken IgY</font></span> </li> </ul><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><font size="4"><strong>Hybridoma cDNA cloning </strong></font> <p align="justify"><font size="3">ModiQuest Research provides the cloning of antibody-coding cDNA from existing hybridomas into various antibody formats (e.g. human or mouse chimeras). This approach allows for the rescue of valuable antibodies from poorly expressing hybridoma clones.</font></p> <p align="justify"><font size="3">ModiQuest Research has a large set of <a href="show.php?id=55">antibody expression vectors</a> allowing the expression of various human and mouse antibody isotypes in CHO, HEK-293 cells. Antibodies can be produced in continuous culture, following stable cell line generation or batch-wise from transiently transfected mammalian cells. </font></p> </font></font></span></p> <p> </p> <p> </p> <p> </p> <p> </p><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Stable antibody producing mammalian cell lines</font></strong></font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">ModiQuest Research provides the generation of stable, high-level antibody producing cell lines. Various mammalian cell lines are used (e.g. CHO, HEK-293, SP/2.0, and NS0). </font></font></span></p> <p align="justify"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">We use </font></font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri">nucleofection and high throughput ClonePix-FL selection technologies in combination with our proprietary vector system. Our approach is fast, efficient, and improves overall throughput. </font></font></span></font></font></span></p><p align="justify"><font face="Calibri" size="4"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><strong>Transient protein production</strong></span></font></p> <p align="justify"><font face="Calibri"><font size="3"><span lang="EN-GB" style="mso-ansi-language: EN-GB">ModiQuest Research provides quick and cost-effective transient antibody production. Trial-batches of a given antibody can be produced in transiently transfected mammalian cell culture. The recombinant antibodies are FPLC-purified from the conditioned culture medium. </span></font></font></p> <p align="justify"><font face="Calibri"><font size="3"><span lang="EN-GB" style="mso-ansi-language: EN-GB">ModiQuest Research has a large set of antibody expression vectors allowing the expression of various recombinant isotypes in CHO or HEK-293 cells. </span></font></font></p> <p align="justify"><font face="Calibri"><font size="3"><span lang="EN-GB" style="mso-ansi-language: EN-GB"></span></font></font><font face="Calibri"><font size="3"><span lang="EN-GB" style="mso-ansi-language: EN-GB">Expression levels of up to 100 mg of purified antibodies can be reached in CHO or HEK-293 cells.</span></font></font></p><p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Our technology platform</font></strong></font></font></span></p> <ul><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri"><font size="3"> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri"><font size="3">Ultra efficient proprietary hybridoma fusion</font></font></span> </p> </li> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri"><font size="3">High-throughput cell sorting, ClonePix FL</font></font></span> </p> </li> </font></font></span> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri"><font size="3">Highly efficient Nucleofection, Amaxa</font></font></span> </p> </li> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">Antibody production in hybridom cell culture, CHO or HEK-293 cell lines</font></span> </p> </li> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">F</font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">PLC-based antibody purification, AKTA</font></span> </p> </li> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">Proprietary mammalian expression vector set, pMQR</font></span> </p> </li> <li> <p><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">(</font></span><span lang="EN-GB" style="mso-ansi-language: EN-GB"><font face="Calibri" size="3">Bio)Assay development and Quality Control</font></span> </p> </li> </ul><p><span style="LINE-HEIGHT: 115%; FONT-FAMILY: Calibri; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><strong><font size="4">Antibodies </font></strong></span></p> <p><span style="LINE-HEIGHT: 115%; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><font face="Calibri"><span style="mso-spacerun: yes">ModiQuest Research offers:</span></font></span><font size="3"> </font></p> <ul type="square"> <li style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; COLOR: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt" class="MsoNormal"><font face="Calibri"><font size="3"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">various unique </span><span style="COLOR: maroon; mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_48_49" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">propietary human and mouse anti-citrullin containing protein/peptide antibodies</span></a></span></font><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"> for proteomic and diagnostic applications. </font></span></font></li> <li style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; COLOR: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt" class="MsoNormal"><font face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"></span></font><font size="3"><font face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">various </span></font><font face="Calibri"><span style="COLOR: maroon; mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">human autoantigens</span></a>: </span></font><font face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">apoptotic cleavage products of the </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26_27" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">hU1-70K protein</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26_27" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">hU1-C protein</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26_29" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">hJo-1 protein</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26_38" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">hRpp20 protein</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_26_39" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">hRrp4 protein</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"> </span></font></font></li> <li style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; COLOR: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt" class="MsoNormal"><font face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"></span></font><font face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">a <font color="#000000">set of </font></span><span style="COLOR: maroon; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"><font color="#000000">unique antibodies</font></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"><font color="#000000"> directed</font> against above mentioned human autoantigens and and protein modifications potentially involved in human disease. </span> </font></span></font></li> <li style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; COLOR: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt" class="MsoNormal"><font face="Calibri"><font size="3"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">anti human TNF antibodies, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_34" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">anti-Tag antibodies</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"> (i.e. HIS, GST, EBFP), </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_35" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">anti collagen antibodies</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, </span><span style="mso-bidi-font-family: Arial"><a href="http://www.modiquestresearch.com/shop/index.php?cPath=21_36" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB">anti IgY antibodies</span></a></span><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">, and antibodies specific for enzymes. </span></font></font></li> </ul> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; COLOR: black; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt" class="MsoNormal"><font face="Calibri"><font size="3"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"></span></font></font></p> <font size="3" face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB"> <p align="justify"><font size="3" face="Calibri"><span style="mso-bidi-font-family: Arial; mso-ansi-language: EN-GB" lang="EN-GB">For an overview of our antibodies and to purchase our antibodies online, </span></font><span><a href="http://www.modiquestresearch.com/shop"><span style="COLOR: #810081; mso-ansi-language: EN-GB" lang="EN-GB"><font size="3" face="Calibri">please click here to enter our websho</font></span><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font color="#800080" size="3" face="Calibri">p</font></span></a></span><span style="COLOR: black; mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><font face="Calibri"><font color="#800080"><a href="javascript:void(0);/*1254329819023*/">.</a></font></font></font></span></p> </span></font><p><strong><font face="Calibri" size="4">Peptidyl Arginine Deiminase (PAD) products</font></strong><span style="font-family: Calibri; color: black; font-size: 12pt;"> </span> </p> <ul type="square" style="margin-top: 0cm;"> <li style="text-align: justify; margin: 0cm 0cm 10pt; color: black;" class="MsoNormal"><font size="3"><strong><span lang="EN-GB" style="font-family: Calibri; font-weight: normal;">ModiQuest Research</span></strong><span lang="EN-GB" style="font-family: Calibri;"> has developed a sensitive antibody based assay to test for Peptidyl Arginine Deiminase (PAD) activity (ABAP). The ABAP is an Enzyme Linked-Immuno-Sorbent Assay (ELISA) for the determination of PAD enzyme activity in cell and tissue lysates. </span></font> </li> </ul> <p style="text-align: justify; margin: 0cm 0cm 10pt;" class="MsoNormal"><span lang="EN-GB" style="font-family: Calibri; color: black;"><font size="3">         <span>   </span>Main advantages over currently used assays:</font></span> </p> <span lang="EN-GB" style="font-family: Calibri; color: black; font-size: 12pt;">                     -<span>  </span>more powerful method to rapidly screen for PAD activity </span> <br/> <span lang="EN-GB" style="font-family: Calibri; color: black; font-size: 12pt;">                     -  more robust </span> <br/> <span lang="EN-GB" style="font-family: Calibri; color: black; font-size: 12pt;">                     -  at least 500 times more sensitive</span>  <ul> <li><span lang="EN-GB" style="font-family: Wingdings; color: black; font-size: 12pt;"><span><span style="font: 7pt "Times New Roman";"></span></span></span><span lang="EN-GB" style="font-family: Calibri; color: black; font-size: 12pt;">ModiQuest Research provides purified recombinant human and mouse Peptidyl  Arginine Deiminase (PAD) enzymes for research applications.</span>  </li> </ul> <p style="text-align: justify; text-indent: -18pt; margin: 0cm 0cm 10pt;" class="MsoNormal"><font size="3"><span lang="EN-GB" style="font-family: Calibri; color: black;">       <span>           </span>Application:</span><span lang="EN-GB" style="font-family: Calibri; color: black;"> </span></font> </p> <p style="text-align: justify; text-indent: -70.9pt; margin: 0cm 0cm 10pt 70.9pt;" class="MsoNormal"><span lang="EN-GB" style="font-family: Calibri;"><font size="3"><span>                   </span>-  proteomic analysis and identification of compounds that may be involved in the ontogeny of various autoimmune diseases like Rheumatoid Arthritis and Multiple Sclerosis. </font></span> </p> <p style="text-align: justify; text-indent: -0.05pt; margin: 0cm 0cm 10pt 0.05pt;" class="MsoNormal"><span lang="EN-GB" style="font-family: Calibri;"><font size="3">For an overview of our antibodies and to purchase our antibodies online, </font><a href="http://www.modiquestresearch.com/shop" target="_blank"><u><span style="color: rgb(129, 0, 129);"><font size="3">please click here to enter our websho</font></span></u></a><a href="http://www.modiquestresearch.com/shop" target="_blank"><u><span style="color: purple;"><font size="3">p</font></span></u></a><font size="3"><span style="color: purple;">. </span></font></span> </p> <p style="margin-left: 0.05pt;"><span lang="EN-GB" style="font-family: Calibri; color: black; font-size: 12pt;">Spec. sheet about the <a href="http://www.modiquestresearch.com/website/downloads/download.php?id=41" target="_blank">MQR-ABAP assay</a> </span></p><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><font face="Calibri">  <p><font size="3"><strong></strong></font></p> <p><strong><font size="4">Products</font></strong></p> <p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 10pt" class="MsoNormal"><font size="3"><span class="bodytext"><span style="mso-ansi-language: EN-GB" lang="EN-GB">Next to contract research, ModiQuest Research sells unique antibodies and products for research and diagnostic applications. We offer several </span></span><span style="mso-ansi-language: EN-GB" lang="EN-GB">Peptidyl Arginine Deiminase (PAD) products and antibodies <span class="bodytext">for the generation of a collagen antibody induced arthritis (CAIA) model. </span></span></font></p> </font></font></span><p><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><font face="Calibri"><strong><font size="4">Arthritis animal model</font></strong> <p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 10pt" class="MsoNormal"><font size="3"><strong><span style="FONT-FAMILY: Calibri; FONT-WEIGHT: normal; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold" lang="EN-GB"></span></strong></font></p> <font size="3"><strong><span style="FONT-FAMILY: Calibri; FONT-WEIGHT: normal; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold" lang="EN-GB"> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class="MsoNormal"><font size="3"><strong><span style="FONT-FAMILY: Calibri; FONT-WEIGHT: normal; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold" lang="EN-GB">ModiQuest Research</span></strong><span style="mso-ansi-language: EN-GB" lang="EN-GB"> has developed an efficient mix of anti-collagen antibodies for the generation of a collagen antibody induced arthritis (CAIA) mouse animal model. </span></font><span style="mso-ansi-language: EN-GB" lang="EN-GB"><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font size="3">The CAIA model is ideal for rapid screening of novel arthritis therapeutics and to study the mechanisms involved in the development of arthritis. </font></span></span> </p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class="MsoNormal"><font size="3"><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"></span></font></p> <font size="3"><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"></span></font><span style="mso-ansi-language: EN-GB" lang="EN-GB"><font size="3">Main advantages of our model: <ul> <li><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"><font size="3">severe arthritis is induced within 24-48 hours instead of 4 weeks </font></span></li> <li><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"><font size="3">ideal for rapid screening of therapeutics for the treatment of arthritis </font></span></li> <li><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"><font size="3">ideal to study </font></span><font size="3"><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB">the mechanisms involved in the development of arthritis. </span></font>      </li> </ul> </font></span>The CAIA antibodies can be delivered directly to clients for in-house animal model generation. Alternatively, complete animal studies using these CAIA antibodies can be provided by ModiQuest Research.   <p><span style="mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"><font size="3"><font size="3" face="Calibri"><span style="mso-ansi-language: EN-GB; mso-bidi-font-family: Arial" lang="EN-GB">For an overview of our antibodies and to purchase our antibodies online, </span></font><span><a href="http://www.modiquestresearch.com/shop" target="_blank"><span style="COLOR: #810081; mso-ansi-language: EN-GB" lang="EN-GB"><u><font size="3" face="Calibri">please click here to enter our websho</font></u></span></a><a href="http://www.modiquestresearch.com/shop" target="_blank"><span style="mso-ansi-language: EN-GB" lang="EN-GB"><u><font color="#800080" size="3" face="Calibri">p</font></u></span></a></span><span style="COLOR: black; mso-ansi-language: EN-GB" lang="EN-GB"><font size="3"><font face="Calibri"><font color="#800080">. </font></font></font></span> <p><font size="3">Spec. sheet about the <a href="http://www.modiquestresearch.com/website/downloads/download.php?id=42" target="_blank"><u><font color="#0000ff">MQR-CAIA antibody model</font></u></a></font></p> </font></span></p> </span></strong></font></font></font></span></p><span style="LINE-HEIGHT: 115%; COLOR: black; FONT-SIZE: 12pt; mso-bidi-font-family: Arial"><font face="Calibri"><span style="mso-spacerun: yes">  <p style="TEXT-ALIGN: justify; MARGIN: 0cm 0cm 10pt" class="MsoNormal"><b style="mso-bidi-font-weight: normal"><span style="LINE-HEIGHT: 115%; FONT-SIZE: 12pt; mso-ansi-language: EN-GB" lang="EN-GB"><font size="4">Novel Therapeutics</font></span></b> </p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span class="bodytext"><span style="mso-ansi-language: EN-GB" lang="EN-GB">ModiQuest Research’s sister company ModiQuest </span></span><span style="COLOR: black; mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB">develops and commercializes novel proprietary therapeutic and diagnostic antibodies for rheumatoid arthritis and inflammatory disorders. </span></font><span style="COLOR: black; mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"><font size="3"> </font></span></p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt" class="MsoNormal"><span style="COLOR: black; mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB"></span> </p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB">The focus of our </span><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-US">therapeutics program is the discovery of novel targets, lead generation and pre-clinical development. Our novel targets w</span><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: NL" lang="EN-GB">ill be patented, marketed and/or out-licensed to diagnostic and/or pharmaceutical companies.</span><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-GB"> </span><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-US">Currently we have two therapeutic compound families for rheumatoid arthritis in the preclinical development phase.</span></font><font size="3"><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-US"> </span></font></p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-US"></span></font> </p> <p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class="MsoNormal"><span style="COLOR: black; mso-bidi-font-family: Arial; mso-ansi-language: EN-US; mso-fareast-language: NL" lang="EN-US"><font size="3">Go to our <a href="http://www.modiquest.com/" target="_blank"><u><font color="#810081">ModiQuest website</font></u></a> for more information</font></span></p> </span></font></span> >